Baldwin's rules

Baldwin's rules in organic chemistry are a series of guidelines outlining the relative favorabilities of ring closure reactions in alicyclic compounds. They were first proposed by Jack Baldwin in 1976. The rules classify ring closures in three ways: Thus, a ring closure reaction could be classified as, for example, a 5-exo-trig. Reaction of methyl 4-hydroxy-2-methylenebutanoate according to Baldwin rules There are sometimes exceptions to Baldwin's rules. For example, cations often disobey Baldwin's rules, as do reactions in which a third-row atom is included in the ring.

Baldwin's rules

Baldwin's rules in organic chemistry are a series of guidelines outlining the relative favorabilities of ring closure reactions in alicyclic compounds. They were first proposed by Jack Baldwin in 1976. The rules classify ring closures in three ways: Thus, a ring closure reaction could be classified as, for example, a 5-exo-trig. Reaction of methyl 4-hydroxy-2-methylenebutanoate according to Baldwin rules There are sometimes exceptions to Baldwin's rules. For example, cations often disobey Baldwin's rules, as do reactions in which a third-row atom is included in the ring.