The Brandywine Highway is a north–south limited-access highway in the vicinity of the city of Binghamton, New York, in the United States. The highway is maintained by the New York State Department of Transportation and extends for 3.95 miles (6.36 km) through Downtown Binghamton and the neighboring village of Port Dickinson. The southern terminus of the highway is at New York State Route 434 (NY 434) in Binghamton and its northern terminus is at Interstate 88 (I-88) in Fenton just north of the Port Dickinson village line.