The Dr. William W. Mayo House, located at 118 North Main Street in Le Sueur, Minnesota, United States, is listed on the National Register of Historic Places (NRHP). It was built in 1859 by James Mayo and his brother, William Worrall Mayo who emigrated from Salford, United Kingdom, to the United States in 1846 and became a doctor. William's older son, William James Mayo was born in the home in 1861. William W. Mayo aided pioneers and their families during the Dakota War of 1862 and later moved to Rochester where he became the examining surgeon for the southern Minnesota Civil War draft board. He and his sons, William and Charles founded the 27-bed Saint Marys Hospital which opened in 1889 following the 1883 Rochester tornado. They later founded their namesake, the Mayo Clinic.