Euclid Avenue is a major street in Cleveland, Ohio. It runs northeasterly from the Public Square in Downtown Cleveland, through the cities of East Cleveland, Euclid and Wickliffe, to the suburb of Willoughby as a part of U.S. Route 20 and U.S. Route 6. The street passes Playhouse Square, the University Circle, Cleveland State University, the Cleveland Clinic, Severance Hall, Tifereth Israel (The Temple), Case Western Reserve University and University Hospitals Case Medical Center. The HealthLine bus rapid transit line runs in designated bus lanes in the median of Euclid Avenue from Public Square to Louis Stokes Station at Windermere in East Cleveland.