Francisco Tenamaztle (fl. 1540s–1550s), also Tenamaxtlan, Tenamaxtli or Tenamaxtle, was a leader of the Caxcan Indians in Mexico during the Mixton War of 1540–1542. He was later put on trial in Spain. With the support of Bartolomé de las Casas he defended the justice of his cause by appealing to King Carlos I.