Guacanagaríx (alternate transcriptions: Guacanacaríc, Guacanagarí) was one of the five Taíno caciques of Hispaniola (island) at the date of its European discovery in 1492, by the first of the Voyages of Christopher Columbus for Spain. He was the chief of the cacicazgo of Marién, which occupied northwest of the island. Guacanagaríx refused to cooperate with other caciques, who tried to expel the Spanish from the Colony of Santo Domingo. He was forced to flee to the mountains, where he later died.