Harlem Avenue is a major north-south street in Chicago, Illinois, United States and the west/southwest/northwest suburbs. It stretches from Glenview Road in Glenview to W County Line Road (328th Street) in Peotone. At 54.1 miles it is the second-longest street in the United States, just after O Street in Nebraska. For most of its length it carries Illinois Route 43. There is a stop along the Metra BNSF Line at Harlem Avenue and Windsor Avenue in Berwyn, Illinois. North of Glenview Road, Harlem Avenue is known as Lehigh Avenue.