Madhouse: A Tragic Tale of Megalomania and Modern Medicine is a 2005 book by the psychiatric sociologist Andrew Scull which discusses the work of controversial psychiatrist Henry Cotton at Trenton State Hospital in New Jersey in the 1920s. Cotton became convinced that insanity was fundamentally a toxic disorder and he surgically removed body parts to try to improve mental health. This often began with the removal of teeth and tonsils: One reviewer called Madhouse "a fine piece of historical research with a modern relevance", and added that "it makes compelling reading".