New York State Route 425 (NY 425) is a north–south state highway in the western portion of New York in the United States. It extends for 23.85 miles (38.38 km) from an interchange with Interstate 290 (I-290) in the town of Tonawanda to an intersection with NY 18 on the shore of Lake Ontario in the village of Wilson. As it heads north, it connects to several regionally important routes, including U.S. Route 62 (US 62) and NY 104. The section between I-290 and the city of North Tonawanda is a four-lane arterial known as the Twin Cities Memorial Highway. North of the city, the route is primarily a two-lane rural highway.