Old Wythe Historic District is a national historic district located at Hampton, Virginia. The district encompasses 2,076 contributing buildings, 1 contributing site, and 1 contributing structure in a primarily residential area of Hampton. The residences include notable examples of the Greek Revival, Queen Anne, Colonial Revival, Tudor Revival, and Mission Revival styles. The district first developed in the 1880s, and is composed generally of six primary subdivisions with the last platted in the 1930s. The earliest building is the John Simpson House (1849).