Pequawket Brook is a 6.4-mile-long (10.3 km) stream near the White Mountains of New Hampshire in the United States. It lies within the watershed of the Saco River, which flows to the Atlantic Ocean in Maine. The brook is under the jurisdiction of the New Hampshire Comprehensive Shoreland Protection Act. New Hampshire Route 113 follows the brook in northern Madison. NH-16 follows the brook from NH-113 to Conway village. The Conway Branch rail line follows the brook and ponds.