Preston House, also known as the John Cole House and Johns(t)on House, is a historic home located at Salem, Virginia. It was built about 1821, and is a two-story, five bay, Federal style brick I-house dwelling. It features a single pile, central passage plan and original rear ell, its exterior end chimneys and decorative brick cornices. It was added to the National Register of Historic Places in 2005, with a boundary amendment in 2006.