SS David E. Hughes (MC contract 1666) was a Liberty ship built in the United States during World War II. She was named after David E. Hughes, an American musician, professor, and inventor. The ship was laid down at the California Shipbuilding Corporation in Los Angeles, California, on 10 May 1943, then launched on 31 May 1943. She survived the war, but was scuttled with obsolete ammunition in 1970.