San Miguel de Asile was a Spanish Franciscan mission built in the early 17th century in the Florida Panhandle, near the present-day town of Lamont, Florida. It was part of Spain's effort to colonize the region, and convert the Timucua and Apalachee people to Christianity. The mission served a local chiefdom of the Timucua people known as the Yustaga. It lasted until the first decade of the 18th century, when it was destroyed, possibly by Creek Indians and the English. The site where the mission stood was added to the U.S. National Register of Historic Places on December 17, 1974.