Spermacoce neoterminalis, the Everglades Key false buttonweed, is a species of plants in the Rubiaceae. It is endemic to southern Florida, from the Everglades as far north as Lake Okeechobee. Spermacoce neoterminalis is a perennial herb with a woody root. Stems are up to 40 cm tall, generally not branching above the ground. Leaves are elliptical. Flowers are small, white, clustered in terminal and axillary glomerules.