St. Nicholas Orthodox Church and Rectory is a historic church at 64-66 Forrester Street in Salem, Massachusetts. The church was built in 1908 for a congregation of immigrants from eastern Europe that had been established in 1901. The wood frame building was designed by local architect William Devereaux Dennis. Its main facade is finished with flushboard siding, while the other elevations are sheathed in clapboards. The center of main facade is dominated by a tower that is initially square, but is topped by an octagonal belfry section and an onion dome with a cross-shaped spire. The facade is flanked by small square towers topped by onion domes. Behind the church stands a Colonial Revival rectory building that was built several years after the church.