The 1992 South Carolina United States House of Representatives elections were held on November 6, 1992 to select six Representatives for two-year terms from the state of South Carolina. The primary elections for the Democrats and the Republicans were held on June 9. Four incumbents were re-elected, but incumbent Democrat Liz J. Patterson of the 4th congressional district was defeated for re-election by Republican Bob Inglis. The open seat in the 6th congressional district remained with the Democrats and the composition of the state delegation after the elections was even at three Republicans and three Democrats.