The 1880 Open Championship was the 20th Open Championship, held 9 April at Musselburgh Links, Musselburgh, East Lothian, Scotland. Bob Ferguson won the Championship, by five strokes from runner-up Peter Paxton. A number of players were absent because of the short notice given for the competition. Jamie Anderson, winner of the previous three Open Championships was amongst those that were missing. Good weather brought out a large number of spectators. The Championship was played over four rounds of the nine-hole Musselburgh course.