The 1965 All-Ireland Under-21 Hurling Championship final was a hurling match that was played to determine the winners of the 1965 All-Ireland Under-21 Hurling Championship, the second season of the All-Ireland Under-21 Hurling Championship, a tournament organised by the Gaelic Athletic Association for the champion teams of the four provinces of Ireland. The final was contested by Wexford of Leinster and Tipperary of Munster, with Wexford winning by 3-7 to 1-4. Wexford's All-Ireland victory was their very first. As of 2015 it remains their only All-Ireland title in the under-21 grade.