The 2006 Dr. Pepper Big 12 Championship Game was held on December 2, 2006 at Arrowhead Stadium in Kansas City, Missouri, and pit the divisional winners from the Big 12 Conference: the Nebraska Cornhuskers, winner of the North division against the Oklahoma Sooners, winner of the South division. The Sooners defeated the Cornhuskers, 21-7. This was the first time the two teams had ever met in the Big 12 conference championship game.