The Anderson-Shaffer House is a historic residence in the city of Hamilton, Ohio, United States. Constructed in the middle of the nineteenth century, it was home to a succession of owners in its early years, and it has been named a historic site. In early 1974, the Anderson-Shaffer House was listed on the National Register of Historic Places, qualifying because of its historic architecture and because of its place as the home of a leading local citizen, William Anderson. It is one of more than eighty National Register-listed properties countywide.