Buckeye Station was built in 1797 by General Nathaniel Massie, a surveyor and early Ohio settler, who lived there for a brief time. It is located just east of Manchester, Ohio, in the uplands overlooking the Ohio River. Massie founded several towns in Ohio, including nearby Manchester, Ohio as well as the state's first capital Chillicothe. Massie leased the property to John Moore for a time, and then sold it to his brother-in-law Charles Willing Byrd.