The Charles Rice Ames House is a historic residence in the city of Belpre, Ohio, United States. Built in 1843 in the Greek Revival style of architecture, the house has been named the region's most outstanding Greek Revival structure. In 1978, the Ames House was listed on the National Register of Historic Places, qualifying for the Register because of its historic architecture, which was seen as significant throughout the local area. It is one of four Belpre locations on the Register, along with the Sixth Street Railroad Bridge, the Captain Jonathan Stone House, and Spencer's Landing.