Chemically induced dimerization
The first small molecule CID system was developed in 1993 and used FK1012, a derivative of the drug tacrolimus (FK506), to induce homo-dimerization of FKBP. This system was used in vivo to induce binding between cell surface receptors which could not bind in the normal way because they lacked transmembrane and extracellular domain. Addition of FK1012 to the cells caused signal transduction.
primaryTopic
Chemically induced dimerization
The first small molecule CID system was developed in 1993 and used FK1012, a derivative of the drug tacrolimus (FK506), to induce homo-dimerization of FKBP. This system was used in vivo to induce binding between cell surface receptors which could not bind in the normal way because they lacked transmembrane and extracellular domain. Addition of FK1012 to the cells caused signal transduction.
has abstract
25بك هذه المقالة تحتاج للمزيد ...... رات والتسبب في تنشيط البروتين.
@ar
Die chemisch induzierte Dimeri ...... merisierungsinduktors erfolgt.
@de
The first small molecule CID s ...... ls caused signal transduction.
@en
Wikipage page ID
37,102,865
Wikipage revision ID
743,807,445
subject
hypernym
type
comment
25بك هذه المقالة تحتاج للمزيد ...... رات والتسبب في تنشيط البروتين.
@ar
Die chemisch induzierte Dimeri ...... merisierungsinduktors erfolgt.
@de
The first small molecule CID s ...... ls caused signal transduction.
@en
label
Chemically induced dimerization
@en
Chemisch induzierte Dimerisierung
@de
مثنوي مستحث كيميائيا
@ar
