Don Luís de Velasco (f. 1561-1571), also known as Paquiquino, was a Native American, possibly of the Kiskiack or Paspahegh tribe, from Tidewater Virginia. In 1561 he was taken by a Spanish expedition. He traveled with them ultimately to Spain, Cuba and Mexico, where he was baptized as Don Luís de Velasco and educated. Don Luís returned to Virginia in 1571 as guide and interpreter for a party of Jesuit missionaries. He is believed to have taken part in a later massacre of the Jesuits at this site, when the region was struggling with famine.