The East Main–High Street Historic District is a historic district roughly bounded by Church, High, E. Main and Franklin Streets in Greenfield, Massachusetts. It encompasses a predominantly residential area just east of Greenfield's central business district, and abuts the Main Street Historic District. The area has historically been where the town's wealthier residents lived, and features a wide variety of styles, with those of the mid-to-late 19th century predominating. The Colonial Revival Weldon Hotel sits just outside the district on High Street.