GTS-21
GTS-21 (DMBX-A) is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent. Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence, and, most significantly, for schizophrenia.
primaryTopic
GTS-21
GTS-21 (DMBX-A) is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent. Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence, and, most significantly, for schizophrenia.
has abstract
GTS-21 (DMBX-A) is a derivativ ...... nificantly, for schizophrenia.
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FDA UNII code
8S399XDN2K
IUPAC name
3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine
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PubChem
thumbnail
Wikipage page ID
17,716,034
Wikipage revision ID
719,304,479
molecular weight
3.08374e+2
smiles
COc2ccccc2C=C1CCCN=C1c3cnccc3
synonyms
(3-anabaseine)
verifiedrevid
424,686,441
hypernym
comment
GTS-21 (DMBX-A) is a derivativ ...... nificantly, for schizophrenia.
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label
GTS-21
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