The H.C. Pitney Variety Store Building is a commercial building in downtown Tampico, Illinois, United States. The building was constructed in 1900 but is probably most notable for its upstairs tenants from 1919–1920. During this period, H.C. Pitney operated the building as the H.C. Pitney Variety Store, and the second-floor apartment was occupied by the family of 40th U.S. President Ronald Reagan. The building is part of a two-story commercial block along Main Street. It is listed as a contributing property to the Tampico Main Street Historic District, which was added to the U.S. National Register of Historic Places in 1982.