Byrons, or J. Byrons or Jackson Byrons, was an American mid-priced department store chain in Miami, Florida. Byrons was founded in 1896 as a pharmacy called Byrons Red Cross. In 1947, the Byrons flagship store on Flagler Street was renamed Byrons Department Store. In April, 1958, Jackson's Stores bought Byron's, adding it to their existing six store chain and renaming the stores Jackson-Byron's. Pharmacy chain Eckerd Corporation bought J. Byron, which at the time comprised 12 stores, in 1968. They sold the chain in 1985.