JQ1
JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma. It was developed by the James Bradner laboratory at Brigham and Women's Hospital and named after chemist Jun Qi. The chemical structure was inspired by patent of similar BET inhibitors by Mitsubishi Tanabe Pharma [WO/2009/084693]. Structurally it is related to benzodiazepines. While widely used in laboratory applications, JQ1 is not itself being used in human clinical trials because it has a short half life.
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primaryTopic
JQ1
JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma. It was developed by the James Bradner laboratory at Brigham and Women's Hospital and named after chemist Jun Qi. The chemical structure was inspired by patent of similar BET inhibitors by Mitsubishi Tanabe Pharma [WO/2009/084693]. Structurally it is related to benzodiazepines. While widely used in laboratory applications, JQ1 is not itself being used in human clinical trials because it has a short half life.
has abstract
JQ1 is a thienotriazolodiazepi ...... ause it has a short half life.
@en
JQ1 — органическое соединение, ...... ости при попадании в организм.
@ru
Le « JQ1 », nommé en l’honneur ...... me contraceptif oral masculin.
@fr
CAS number
1268524-70-4
IUPAC name
(S)-tert-butyl 2-(4-(4-chlorop ...... 3-a][1,4]diazepin-6-yl)acetate
@en
PubChem
thumbnail
Wikipage page ID
36,949,002
Wikipage revision ID
739,197,394
ChemSpiderID
26,323,622
IUPHAR ligand
molecular weight
4.56987e+2
smiles
Cc3sc1-n2cnnc2CN=Cc4ccccc4
StdInChIKey
DNVXATUJJDPFDM-KRWDZBQOSA-N
hypernym
comment
JQ1 is a thienotriazolodiazepi ...... ause it has a short half life.
@en
JQ1 — органическое соединение, ...... кции и некоторых форм лейкоза.
@ru
Le « JQ1 », nommé en l’honneur ...... me contraceptif oral masculin.
@fr
label
JQ1
@en
JQ1
@fr
JQ1
@ru
