The Jeannie River is a river located in Far North Queensland, Australia. The headwaters of the river rise in the Great Dividing Range in the northern portion of the Cape York Peninsula in Kalpowar Aboriginal Land northwest of Hope Vale and west of Starke. The river flows in a north easterly direction through mostly uninhabited country past Lagoon Prospect and then enters the Cape Melville National Park and eventually discharging into the Coral Sea almost adjacent to Howick Island. The river descends 230 metres (750 ft) over its 43-kilometre (27 mi) course.