Josiah Charles Trent (7 August 1914–10 December 1948) was an American surgeon and a historian of medicine. He is notable for his collection of rare books and manuscripts documenting the history of western medicine. After his death, his widow, Mary Duke Biddle Trent Semans, donated his collection of books to Duke University. Today, this collection forms the foundation of the History of Medicine Collections in the David M. Rubenstein Rare Book & Manuscript Library.