KM-233
KM-233 is a drug which is an analogue of Δ8-tetrahydrocannabinol (THC), the less active but more stable isomer of the active component of Cannabis. km-233 differs from Δ8-THC by the pentyl side chain being replaced by a 1,1-dimethylbenzyl group. It has high binding affinity in vitro for both the CB1 and CB2 receptors, with a CB2 affinity of 0.91nM and 13x selectivity over the CB1 receptor. In animal studies it has been found to be effective for the treatment of glioma, a form of brain tumor. A large number of related analogues are known where the 1,1-dimethylbenzyl group is substituted or replaced by other groups, with a fairly well established structure-activity relationship.
primaryTopic
KM-233
KM-233 is a drug which is an analogue of Δ8-tetrahydrocannabinol (THC), the less active but more stable isomer of the active component of Cannabis. km-233 differs from Δ8-THC by the pentyl side chain being replaced by a 1,1-dimethylbenzyl group. It has high binding affinity in vitro for both the CB1 and CB2 receptors, with a CB2 affinity of 0.91nM and 13x selectivity over the CB1 receptor. In animal studies it has been found to be effective for the treatment of glioma, a form of brain tumor. A large number of related analogues are known where the 1,1-dimethylbenzyl group is substituted or replaced by other groups, with a fairly well established structure-activity relationship.
has abstract
KM-233 is a drug which is an a ...... ructure-activity relationship.
@en
ATC prefix
CAS number
628263-22-9
IUPAC name
(−)-(6aR,7,10,10aR)-tetrahydro ...... hyl)-6H-dibenzo[b,d]pyran-1-ol
@en
thumbnail
Wikipage page ID
36,033,185
Wikipage revision ID
713,207,382
ChEMBL
ChemSpiderID
molecular weight
3.62503e+2
smiles
CC1=CC[C@@H]2[C@@H]C3=CO
StdInChIKey
GZYXCXRHVALIJD-WOJBJXKFSA-N
comment
KM-233 is a drug which is an a ...... ructure-activity relationship.
@en
label
KM-233
@en