L-655,708
L-655,708 (FG-8094) is a nootropic drug invented in 1996 by a team working for Merck, Sharp and Dohme, that was the first compound developed which acts as a subtype-selective inverse agonist at the α5 subtype of the benzodiazepine binding site on the GABAA receptor. It acts as an inverse agonist at the α1, α2, α3 and α5 subtypes, but with much higher affinity for α5, and unlike newer α5 inverse agonists such as α5IA, L-655,708 exerts its subtype selectivity purely via higher binding affinity for this receptor subtype, with its efficacy as an inverse agonist being around the same at all the subtypes it binds to.
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primaryTopic
L-655,708
L-655,708 (FG-8094) is a nootropic drug invented in 1996 by a team working for Merck, Sharp and Dohme, that was the first compound developed which acts as a subtype-selective inverse agonist at the α5 subtype of the benzodiazepine binding site on the GABAA receptor. It acts as an inverse agonist at the α1, α2, α3 and α5 subtypes, but with much higher affinity for α5, and unlike newer α5 inverse agonists such as α5IA, L-655,708 exerts its subtype selectivity purely via higher binding affinity for this receptor subtype, with its efficacy as an inverse agonist being around the same at all the subtypes it binds to.
has abstract
L-655,708 (FG-8094) is a nootr ...... n animal models of depression.
@en
CAS number
130477-52-0
IUPAC name
ethyl (13aS)-7-methoxy-9-oxo-1 ...... 4]benzodiazepine-1-carboxylate
@en
PubChem
thumbnail
Wikipage page ID
19,182,387
Wikipage revision ID
737,674,334
ChEMBL
ChemSpiderID
molecular weight
smiles
CCOCc1c2n-c3cccOC
StdInChIKey
YKYOQIXTECBVBB-AWEZNQCLSA-N
Verifiedfields
verifiedrevid
444,649,300
Watchedfields
subject
comment
L-655,708 (FG-8094) is a nootr ...... all the subtypes it binds to.
@en
label
L-655,708
@en