Lupinus duranii is a species of lupine known by the common name Mono Lake lupine. It is endemic to California, where it is known mainly from the eastern slopes of the Sierra Nevada in western Mono County. Its distribution includes Mammoth Mountain and the hills around Mono Lake, and its habitat has gravelly, pumice-rich soils of volcanic origin. It is almost identical to the nominate variety of Brewer's Lupine, which occurs commonly in the same region. Besides the fact that L. breweri does not occur on pumice flats, the pair are difficult to separate.