Melanophryniscus biancae is a species of toad in the family Bufonidae, first found in the Atlantic Forest in Santa Catarina, Brazil. It is found at intermediate-high altitudes and has a phytotelm-breeding reproductive strategy. It is distinguished from its cogenerate species based on differences in snout-vent length; having white and/or yellow spots on its forearms, mouth, belly and cloaca; the pattern and arrangement of warts; and the presence and number of corneous spines. It might be threatened by habitat loss.