"On the Road Again" is a song recorded by the American blues-rock group Canned Heat in 1967. A driving blues-rock boogie, it was adapted from earlier blues songs and includes mid-1960s psychedelic rock elements. Unlike most of Canned Heat's songs from the period, second guitarist and harmonica player Alan Wilson provides the distinctive falsetto vocal. "On the Road Again" first appeared on their second album, Boogie with Canned Heat, in January 1968; when an edited version was released as a single in April 1968, "On the Road Again" became Canned Heat's first record chart hit and one of their best-known songs.