Pennsylvania Route 75 (PA 75) is a 71.2-mile-long (114.6 km) north–south state highway located in central Pennsylvania. The southern terminus is at the Mason–Dixon line in Montgomery Township, where the road continues into Maryland as Maryland Route 494 (MD 494). The northern terminus is at an interchange with U.S. Route 22 (US 22) and US 322 northeast of Port Royal. PA 75 is a two-lane undivided road that passes through the Ridge-and-Valley Appalachians in Franklin and Juniata counties. The route heads north from the Maryland border in Franklin County to Mercersburg, where it runs concurrent with PA 16 and PA 416. From Mercersburg, PA 75 heads north and crosses US 30 in Fort Loudon before it runs northeast through a long valley, where it has an interchange with the Pennsylvania Turnpike (