Pennsylvania Route 850 (PA 850) is a 44-mile-long (71 km) state highway located in Juniata and Perry Counties in Pennsylvania. The western terminus is at PA 35 in Tuscarora Township. The eastern terminus is at US 11/US 15 in Marysville. PA 850 is a two-lane undivided road that runs through rural areas in the Ridge-and-Valley Appalachians. The route heads southeast from PA 35 and crosses PA 75 in Honey Grove before it traverses Tuscarora Mountain and leaves Juniata County for Perry County. PA 850 continues southeast and crosses PA 17 in Kistler before running east concurrent with PA 274 between Fort Robinson and Loysville. The route turns back to the southeast and heads south concurrent with PA 233 into Landisburg. PA 850 heads east, crossing PA 74 in Alinda before following PA 34 southeast