St. Paul's College was a Jesuit school, and later college, founded circa 1542 by saint Francis Xavier, at Old Goa. It was once the main Jesuit institution in the whole of Asia. It housed the first printing press in India, having published the first books in 1556. The original building, however, was abandoned progressively after the outbreak of plague in 1578, and went into disuse as the college moved to new building known as the New College of Saint Paul.