Santa Susana Depot is a train station building located near the Santa Susana Pass in Simi Valley, California. Originally located on Los Angeles Avenue at Tapo Street, the depot opened in 1903. The Santa Susana Tunnel opened the next year, reducing the distance and transit time between Montalvo and Burbank on the Coast Route linking Los Angeles and San Francisco. Plans and construction for the building were based on Southern Pacific Railroad standard design Two Story Combination Depot No. 22. The depot served the community of Rancho Simi as a passenger station, telegraph office, and freight depot where farmers could deliver crops for shipping and pick up farming equipment delivered by the railroad.