14-Phenylpropoxymetopon
14-Phenylpropoxymetopon (PPOM) is an opiate analogue that is a derivative of metopon which has been substituted with a γ-phenylpropoxy group at the 14-position. It is a highly potent analgesic drug several thousand times stronger than morphine, with a similar in vivo potency to etorphine. The 14-phenylpropoxy substitution appears to confer potent μ-opioid agonist activity, even when combined with substitutions such as N-cyclopropyl or N-allyl, which normally result in μ-opioid antagonist compounds.
primaryTopic
14-Phenylpropoxymetopon
14-Phenylpropoxymetopon (PPOM) is an opiate analogue that is a derivative of metopon which has been substituted with a γ-phenylpropoxy group at the 14-position. It is a highly potent analgesic drug several thousand times stronger than morphine, with a similar in vivo potency to etorphine. The 14-phenylpropoxy substitution appears to confer potent μ-opioid agonist activity, even when combined with substitutions such as N-cyclopropyl or N-allyl, which normally result in μ-opioid antagonist compounds.
has abstract
14-Phenylpropoxymetopon (PPOM) ...... xis following repeated dosing.
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IUPAC name
3-Hydroxy-14-(3-phenylpropoxy)-5-methyl-7,8-dihydro-4,5α-epoxy-17-methylmorphinan-6-one
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PubChem
Wikipage page ID
17,016,674
Wikipage revision ID
713,189,653
ChemSpiderID
molecular weight
smiles
C[C@]12CCC[C@@]3OCCCC6=CC=CC=C6
StdInChIKey
YLXOHYYZBORDAJ-NVSKSXHLSA-N
synonyms
verifiedrevid
477,209,024
Watchedfields
hypernym
comment
14-Phenylpropoxymetopon (PPOM) ...... μ-opioid antagonist compounds.
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label
14-Phenylpropoxymetopon
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