The 1950 Southern Five-Hundred was considered to be the inaugural Southern Five-Hundred (shortened in 1951 to Southern 500) of the NASCAR Grand National event that took place September 4, 1950, at Darlington Raceway in Darlington, South Carolina. It was responsible for turning the Southern 500 into the biggest racing event prior to the 1959 Daytona 500. While this edition of the Southern 500 would be hosted in association with the Central States Racing Association, all of the other Southern 500 races would be hosted exclusively by NASCAR.