The 2010 Colorado Buffaloes football team represented the University of Colorado in the 2010 NCAA Division I FBS football season. The team was coached by fifth-year head coach Dan Hawkins for the first nine games and interim head coach Brian Cabral for the final three games. Colorado played their homes game at Folsom Field. It was also the final season as members the Big 12 Conference in the North Division for Colorado, before joining the Pac-12 Conference for the 2011 season. The Buffaloes failed to qualify for a bowl game, as they finished the season 5–7, 2–6 in Big 12 play.