The 2010 NCRHA Division II Collegiate Roller Hockey National Championships involved 16 schools playing in a round robin followed by a single elimination tournament to determine the national champion of NCRHA Division II college roller hockey. The tournament began on April 7, 2010 and ended with the national championship game on April 11. West Chester University of Pennsylvania, coached by Alex Kozik, won its first national title with a 7–5 victory in the national championship game over Southern Illinois University Edwardsville, coached by Andrew Tucker.