2012 Mutua Madrid Open – Women's Singles

Petra Kvitová was the defending champion, but lost to qualifier Lucie Hradecká in the second round. Serena Williams won the tournament, defeating World No. 1 Victoria Azarenka in straight sets, 6–1, 6–3. Azarenka lost in the final for the second year in a row.

2012 Mutua Madrid Open – Women's Singles

Petra Kvitová was the defending champion, but lost to qualifier Lucie Hradecká in the second round. Serena Williams won the tournament, defeating World No. 1 Victoria Azarenka in straight sets, 6–1, 6–3. Azarenka lost in the final for the second year in a row.