4-Methylamphetamine
4-Methylamphetamine (4-MA; PAL-313; Aptrol; p-TAP) is a stimulant and anorectic drug of the phenethylamine and amphetamine chemical classes. In vitro, it acts as a potent and balanced serotonin, norepinephrine, and dopamine releasing agent with Ki affinity values of 53.4nM, 22.2nM, and 44.1nM at the serotonin, norepinephrine, and dopamine transporters, respectively. However, more recent in vivo studies that involved performing microdialysis on rats showed a different trend. These studies showed that 4-methylamphetamine is much more potent at elevating serotonin (~18 x baseline) relative to dopamine (~5 x baseline). The authors speculated that this is because 5-HT release dampens DA release through some mechanism. For example, it was suggested that a possible cause for this could be activat
primaryTopic
4-Methylamphetamine
4-Methylamphetamine (4-MA; PAL-313; Aptrol; p-TAP) is a stimulant and anorectic drug of the phenethylamine and amphetamine chemical classes. In vitro, it acts as a potent and balanced serotonin, norepinephrine, and dopamine releasing agent with Ki affinity values of 53.4nM, 22.2nM, and 44.1nM at the serotonin, norepinephrine, and dopamine transporters, respectively. However, more recent in vivo studies that involved performing microdialysis on rats showed a different trend. These studies showed that 4-methylamphetamine is much more potent at elevating serotonin (~18 x baseline) relative to dopamine (~5 x baseline). The authors speculated that this is because 5-HT release dampens DA release through some mechanism. For example, it was suggested that a possible cause for this could be activat
has abstract
4-Methylamphetamine (4-MA; PAL ...... ne
* 3,4-Dimethylamphetamine
@en
4-methylamfetamine (doorgaans ...... verhitting van het lichaam op.
@nl
La 4-Méthylamphétamine (4-MA; ...... r la production de sérotonine.
@fr
ATC prefix
CAS number
22683-78-9
IUPAC name
1-(4-methylphenyl)propan-2-amine
@en
PubChem
thumbnail
Wikipage page ID
24,284,447
Wikipage revision ID
714,470,643
Alt
Ball-and-stick model of the 4-methylamphetamine molecule
ChEMBL
ChemSpiderID
elimination half-life
excretion
legal CA
legal DE
legal UK
molecular weight
routes of administration
Oral, intranasal, injection
StdInChIKey
ZDHZDWSHLNBTEB-UHFFFAOYSA-N
Verifiedfields
verifiedrevid
477,222,632
subject
hypernym
comment
4-Methylamphetamine (4-MA; PAL ...... ause for this could be activat
@en
4-methylamfetamine (doorgaans ...... verhitting van het lichaam op.
@nl
La 4-Méthylamphétamine (4-MA; ...... amine, de l'ordre de 4 pour 1.
@fr
label
4-Methylamphetamine
@en
4-Méthylamphétamine
@fr
4-methylamfetamine
@nl