AM-630
AM-630 (6-Iodopravadoline) is a drug that acts as a potent and selective inverse agonist for the cannabinoid receptor CB2, with a Ki of 32.1 nM at CB2 and 165x selectivity over CB1, at which it acted as a weak partial agonist. It is used in the study of CB2 mediated responses and has been used to investigate the possible role of CB2 receptors in the brain. AM-630 is significant as one of the first indole derived cannabinoid ligands substituted on the 6-position of the indole ring, a position that has subsequently been found to be important in determining affinity and efficacy at both the CB1 and CB2 receptors, and has led to the development of a large number of related derivatives.
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AM-630
AM-630 (6-Iodopravadoline) is a drug that acts as a potent and selective inverse agonist for the cannabinoid receptor CB2, with a Ki of 32.1 nM at CB2 and 165x selectivity over CB1, at which it acted as a weak partial agonist. It is used in the study of CB2 mediated responses and has been used to investigate the possible role of CB2 receptors in the brain. AM-630 is significant as one of the first indole derived cannabinoid ligands substituted on the 6-position of the indole ring, a position that has subsequently been found to be important in determining affinity and efficacy at both the CB1 and CB2 receptors, and has led to the development of a large number of related derivatives.
has abstract
AM-630 (6-Iodopravadoline) is ...... number of related derivatives.
@en
CAS number
164178-33-0
IUPAC name
1-[2-(morpholin-4-yl)ethyl]-2-methyl-3-(4-methoxybenzoyl)-6-iodoindole
@en
PubChem
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Wikipage page ID
30,438,930
Wikipage revision ID
732,517,393
ChEMBL
ChemSpiderID
IUPHAR ligand
legal CA
molecular weight
smiles
C4COCCN4CCnc2ccccc2c1Cc3ccccc3
StdInChIKey
JHOTYHDSLIUKCJ-UHFFFAOYSA-N
Verifiedfields
verifiedrevid
477,235,883
subject
hypernym
comment
AM-630 (6-Iodopravadoline) is ...... number of related derivatives.
@en
label
AM-630
@en