A Lady Takes a Chance is a 1943 American romantic comedy film directed by William A. Seiter and starring Jean Arthur and John Wayne. Written by Robert Ardrey and based on a story by Jo Swerling, the film is about a New York working girl who travels to the American West on a bus tour and meets and falls in love with a handsome rodeo cowboy. The film was produced for RKO Radio Pictures by Frank Ross, who was Arthur's husband at the time. The supporting cast features comedian Phil Silvers.