Ambrisentan
Ambrisentan (U.S. trade name Letairis; E.U. trade name Volibris; India trade name Pulmonext by MSN labs) is a drug indicated for use in the treatment of pulmonary hypertension. The peptide endothelin constricts muscles in blood vessels, increasing blood pressure. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2).
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Ambrisentan
Ambrisentan (U.S. trade name Letairis; E.U. trade name Volibris; India trade name Pulmonext by MSN labs) is a drug indicated for use in the treatment of pulmonary hypertension. The peptide endothelin constricts muscles in blood vessels, increasing blood pressure. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2).
has abstract
Ambrisentan (U.S. trade name L ...... ent of pulmonary hypertension.
@en
Ambrisentan ist ein Arzneistof ...... an-Arzneimittel klassifiziert.
@de
L'ambrisentan est un inhibiteu ...... tension artérielle pulmonaire.
@fr
أمبريسينتان (Ambrisentan) يعمل ...... انخفاض ضغط الدم داخل الرئتين.
@ar
アンブリセンタン（Ambrisentan、商品名：ヴォリブリ ...... 004年8月、欧州：2005年5月、日本：2013年6月）。
@ja
ATC prefix
ATC suffix
CAS number
177036-94-1
FDA UNII code
HW6NV07QEC
IUPAC name
(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
@en
PubChem
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Link from a Wikipage to an external page
Wikipage page ID
10,507,123
Wikipage revision ID
738,568,087
bioavailability
ChEMBL
ChemSpiderID
elimination half-life
IUPHAR ligand
legal CA
legal US
licence EU
licence US
molecular weight
3.78421e+2
protein bound
routes of administration
smiles
O=C[C@@H]Cc3ccccc3
StdInChIKey
OUJTZYPIHDYQMC-LJQANCHMSA-N
verifiedrevid
437,179,007
Watchedfields
hypernym
comment
Ambrisentan (U.S. trade name L ...... trials (ARIES-1 and ARIES-2).
@en
Ambrisentan ist ein Arzneistof ...... und in der Schweiz zugelassen.
@de
L'ambrisentan est un inhibiteu ...... tension artérielle pulmonaire.
@fr
أمبريسينتان (Ambrisentan) يعمل ...... انخفاض ضغط الدم داخل الرئتين.
@ar
アンブリセンタン（Ambrisentan、商品名：ヴォリブリ ...... 004年8月、欧州：2005年5月、日本：2013年6月）。
@ja
label
Ambrisentan
@de
Ambrisentan
@en
Ambrisentan
@fr
أمبريسينتان
@ar
アンブリセンタン
@ja
